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Many of the serial killers we cover focused on killing random strangers. That makes their behavior even more disturbing, since in most cases, murderers have personal connections to their victims.

But no serial killer in history has killed more of her own family members than Nannie Doss — also known as the "Giggling Granny." A head injury at a young age, paired with her own obsession with having the "perfect husband," led her on a killing spree that spanned three decades between the 1920s and 1950s. Victims included four of the men she married, two of her own children, her sister, her grandchildren, and two of her mothers-in-law.

In 1923, at age 16, Nannie Doss married Charley Braggs after dating for just four months.

Woman On Killing Spree To Find the Perfect Husband